Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.41 |
| ▸ | GAK | O14976 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | KIF5B | P33176 | 1/20 | 0.37 |
| ▸ | ILK | Q13418 | 1/20 | 0.37 |
| ▸ | BCL6 | P41182 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.36 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.36 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431484 | 0.85 | KDR (0.41) | EGFRGAKKDRFGFR1FLT1 | |
| SCHEMBL6436364 | 0.85 | FLT1 (0.50) | KDRPDGFRBFGFR1FLT1RET | |
| SCHEMBL6435553 | 0.81 | EGFR (0.52) | EGFRGAKKDRFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL6430982 | 0.80 | EGFR (0.52) | EGFRGAKKDRFGFR1FLT1 | |
| SCHEMBL6431478 | 0.76 | FGFR1 (0.62) | EGFRGAKKDRFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL6430782 | 0.75 | FGFR1 (0.61) | EGFRGAKKDRFGFR1FLT1 | |
| SCHEMBL6432228 | 0.75 | FLT1 (0.61) | EGFRKDRFGFR1FLT1 | |
| SCHEMBL6431502 | 0.75 | GAA (0.40) | FGFR1FLT1RETKIF5BALDH1A1 | |
| SCHEMBL6450143 | 0.71 | CTSV (0.45) | EGFRGAKKDRRETKIF5B | |
| SCHEMBL6430845 | 0.70 | FLT1 (0.55) | KDRPDGFRBFGFR1FLT1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | claimed |