Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 5/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.47 |
| ▸ | CASR | P41180 | 4/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6435850 | 1.00 | ADRB2 (0.47) | ADRB2ADRB1ADRB3CASRFNTA | |
| SCHEMBL6432465 | 0.95 | ADRB3 (0.52) | ADRB2ADRB1ADRB3CASRFNTA | |
| SCHEMBL6432460 | 0.95 | ADRB3 (0.52) | ADRB2ADRB1ADRB3CASRFNTA | |
| SCHEMBL6433735 | 0.89 | ADRB1 (0.45) | ADRB2ADRB1ADRB3CASRHCRTR1 | |
| SCHEMBL6433728 | 0.89 | ADRB1 (0.45) | ADRB2ADRB1ADRB3CASRHCRTR1 | |
| SCHEMBL6435843 | 0.86 | ADRB1 (0.43) | ADRB2ADRB1ADRB3CASR | |
| SCHEMBL6436830 | 0.86 | ADRB1 (0.42) | ADRB2ADRB1ADRB3CASR | |
| SCHEMBL6438415 | 0.85 | ADRB2 (0.45) | ADRB2ADRB1ADRB3CNR1 | |
| SCHEMBL6438418 | 0.85 | ADRB2 (0.45) | ADRB2ADRB1ADRB3CNR1 | |
| SCHEMBL6436894 | 0.84 | ADRB1 (0.44) | ADRB2ADRB1ADRB3CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087943-B1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| US-6251925-B1 | AN AGONISTS FOR HUMAN BETA-3 ADRENOCEPTOR | GLAXO WELLCOME INC. | 2001-06-26 | — | — | US | disclosed |