SCHEMBL6435888

SCHEMBL6435888

N#Cc1ccc(Cc2nccn2-c2ccc(C#N)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 4/20 0.42
CYP11B1 P15538 2/20 0.42
CYP11B2 P19099 1/20 0.42
LOXL2 Q9Y4K0 2/20 0.40
MAPKAPK2 P49137 1/20 0.39
AR P10275 1/20 0.39
HRH3 Q9Y5N1 1/20 0.39
ICMT O60725 1/20 0.38
CYP2A6 P11509 1/20 0.38
GRM1 Q13255 1/20 0.37
SAE1 Q9UBE0 1/20 0.36
UBA2 Q9UBT2 1/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
HPGD P15428 1/20 0.36
CYP2C19 P33261 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1507856 0.91 KIF11 (0.45) CYP19A1CYP11B1CYP11B2MAPKAPK2AR
SCHEMBL5597319 0.86 CYP2E1 (0.46) CYP19A1CYP11B1CYP11B2ARHRH3
SCHEMBL27325095 0.83 PDE4A (0.45) CYP19A1CYP11B2MAPKAPK2ICMTCYP2A6
Hydrochloric Acid SCHEMBL10845333 0.80 CYP19A1 (0.40) CYP19A1MAPKAPK2ICMTCYP1A2CYP2D6
SCHEMBL10735832 0.80 CYP19A1 (0.37) CYP19A1CYP11B1CYP11B2LOXL2HRH3
SCHEMBL8411283 0.78 CYP19A1 (0.47) CYP19A1CYP11B1CYP11B2ARKDM4E
SCHEMBL8408613 0.78 CYP19A1 (0.47) CYP19A1CYP11B1CYP11B2ARKDM4E
SCHEMBL1508003 0.78 CYP19A1 (0.50) CYP19A1CYP11B1CYP11B2
SCHEMBL6981310 0.76 HSP90AA1 (0.42) CYP19A1CYP11B1CYP11B2
Benzene SCHEMBL20549155 0.75 L3MBTL1 (0.53) ALDH1A1CYP1A2CYP2D6CYP2C9HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1492515-A1 PHARMACEUTICAL COMPOSITION COMPRISING AN AROMATASE INHIBITOR AND AN ESTROGEN SUITABLE FOR HORMONE REPLACEMENT THERAPY FOR A MALE JENCAP RESEARCH LTD. (CA) 2005-01-05 EP disclosed
WO-2003082254-A1 PHARMACEUTICAL COMPOSITION COMPRISING AN AROMATASE INHIBITOR AND AN ESTROGEN SUITABLE FOR HORMONE REPLACEMENT THERAPY FOR A MALE JENCAP RESEARCH LTD. (CA) 2003-10-09 WO disclosed
EP-0236940-A2 Alpha-heterocycle substituted tolunitriles CIBA-GEIGY AG (CH) 1987-09-16 EP disclosed