Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450611 | 0.87 | SLC6A2 (0.40) | TGFBR1SMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6453841 | 0.84 | SLC6A2 (0.39) | SMN1; SMN2SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL6450409 | 0.81 | MAPK1 (0.40) | SMN1; SMN2SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL6451959 | 0.80 | PDE4B (0.36) | TGFBR1SMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6438072 | 0.79 | HSD17B10 (0.45) | SMN1; SMN2KMT2ALMNAMAPTNPC1 | |
| SCHEMBL9056947 | 0.69 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3PGRDRD2 | |
| SCHEMBL6456177 | 0.69 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3PGRDRD2 | |
| SCHEMBL6461886 | 0.68 | TGFBR1 (0.41) | TGFBR1KMT2AALDH1A1 | |
| SCHEMBL6456034 | 0.68 | TGFBR1 (0.41) | TGFBR1LMNAMAPT | |
| SCHEMBL6454933 | 0.67 | TP53 (0.37) | TGFBR1SMN1; SMN2KMT2ALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539753-A2 | PYRAZOLO(3,4-B)PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-15 | — | — | EP | claimed |
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | claimed |