Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6456034 | 0.89 | TGFBR1 (0.41) | TGFBR1JAK3OPRM1OPRD1OPRK1 | |
| SCHEMBL6453841 | 0.81 | SLC6A2 (0.39) | S1PR1KMT2A | |
| SCHEMBL6464368 | 0.81 | TGFBR1 (0.41) | TGFBR1JAK3JAK2JAK1 | |
| SCHEMBL6458237 | 0.78 | TGFBR1 (0.41) | TGFBR1JAK3ALDH1A1S1PR1JAK2 | |
| SCHEMBL6450611 | 0.77 | SLC6A2 (0.40) | TGFBR1KCNH2MEN1KMT2A | |
| SCHEMBL19444786 | 0.74 | HRH3 (0.50) | OPRM1OPRD1OPRK1KDM1AMEP1B | |
| SCHEMBL6450409 | 0.73 | MAPK1 (0.40) | ALDH1A1MEN1KMT2A | |
| SCHEMBL6454933 | 0.73 | TP53 (0.37) | TGFBR1ALDH1A1S1PR1MEN1KMT2A | |
| SCHEMBL6451777 | 0.70 | KMT2A (0.38) | TGFBR1JAK3JAK2JAK1KMT2A | |
| SCHEMBL6456177 | 0.70 | SLC6A2 (0.42) | OPRM1S1PR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539753-A2 | PYRAZOLO(3,4-B)PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |