Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6453841 | 0.80 | SLC6A2 (0.39) | LMNAS1PR1SMN1; SMN2KMT2A | |
| SCHEMBL6450611 | 0.75 | SLC6A2 (0.40) | LMNATGFBR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6456034 | 0.73 | TGFBR1 (0.41) | LMNATGFBR1S1PR1PROKR1 | |
| SCHEMBL6461886 | 0.73 | TGFBR1 (0.41) | TGFBR1S1PR1ALDH1A1MEN1KMT2A | |
| SCHEMBL5042156 | 0.72 | HRH3 (0.47) | LMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6464368 | 0.72 | TGFBR1 (0.41) | TGFBR1 | |
| SCHEMBL6456250 | 0.70 | KMT2A (0.39) | LMNATGFBR1ALDH1A1PROKR1MEN1 | |
| SCHEMBL6458237 | 0.70 | TGFBR1 (0.41) | LMNATGFBR1S1PR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6450409 | 0.70 | MAPK1 (0.40) | TP53LMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL6451777 | 0.68 | KMT2A (0.38) | TP53LMNATGFBR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539753-A2 | PYRAZOLO(3,4-B)PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |