SCHEMBL6437209

SCHEMBL6437209

NC(=S)c1cccc(Cn2c(C(=O)NCc3ccncc3)cc3cc(F)ccc32)c1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.59
F2 P00734 3/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6436996 0.89 F10 (0.71) F10F2
SCHEMBL6434800 0.83 CCR2 (0.53) F10F2
SCHEMBL6436363 0.80 F10 (0.81) F10F2
SCHEMBL6434131 0.80 F10 (0.59) F10F2
SCHEMBL7712499 0.79 F10 (0.62) F10F2
Trifluoroacetic Acid SCHEMBL6436682 0.79 F10 (0.84) F10F2
Trifluoroacetic Acid SCHEMBL6432601 0.78 F10 (0.77) F10F2
SCHEMBL6432399 0.77 F10 (0.84) F10F2
Acetic Acid SCHEMBL6433311 0.76 F10 (0.90) F10F2
SCHEMBL6433197 0.76 F10 (0.68) F10F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1220681-C Indole derivatives as XA factor inhibitors AVENTIS MEDICINES DEUTSCHLAND (DE) 2005-09-28 CN disclosed
EP-1042287-B1 INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA AVENTIS PHARMA GMBH (DE) 2005-04-20 EP disclosed
US-6337344-B1 ANTICOAGULANTS AND ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-01-08 US disclosed
CN-1283186-A Indole derivatives as XA factor inhibitors AWENTIS MEDICINES DEUTSCHLAND (DE) 2001-02-07 CN disclosed
EP-1042287-A1 INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA Aventis Pharma Deutschland GmbH (DE) 2000-10-11 EP disclosed
WO-1999033800-A1 INDOLE DERIVATIVES AS INHIBITORS OR FACTOR XA AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 1999-07-08 WO disclosed