Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.48 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6436908 | 0.82 | PDK2 (0.50) | SYKPDCD1CD274BCHECA1 | |
| SCHEMBL6432986 | 0.79 | SYK (0.52) | SYKCD274ADRB2ADRB1ADRB3 | |
| SCHEMBL6437284 | 0.79 | PDCD1 (0.47) | PDCD1CD274MALT1DDB1CRBN | |
| SCHEMBL7203913 | 0.76 | MALT1 (0.59) | SYKMALT1DDB1CRBNBCHE | |
| SCHEMBL2875983 | 0.76 | ADRB2 (0.53) | MALT1BCHECA1CA2ADRB2 | |
| SCHEMBL19591348 | 0.74 | MALT1 (0.49) | MALT1DDB1CRBNBCHECA1 | |
| SCHEMBL16011811 | 0.74 | MALT1 (0.49) | MALT1DDB1CRBNBCHECA1 | |
| SCHEMBL5891961 | 0.74 | MAPK1 (0.53) | MALT1BCHECA1CA2MTNR1A | |
| SCHEMBL4899444 | 0.74 | MALT1 (0.54) | MALT1DDB1CRBNBCHEBRD4 | |
| SCHEMBL10126895 | 0.73 | MTNR1A (0.69) | MALT1BCHECA1CA2MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087943-B1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| US-6251925-B1 | AN AGONISTS FOR HUMAN BETA-3 ADRENOCEPTOR | GLAXO WELLCOME INC. | 2001-06-26 | — | — | US | disclosed |