Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6437277 | 0.79 | SYK (0.48) | SYKCD274ADRB1ADRB3ADRB2 | |
| SCHEMBL6432991 | 0.74 | NR1H4 (0.45) | CD274PTGER1 | |
| SCHEMBL16247703 | 0.74 | AKR1C2 (0.51) | SYKL3MBTL1MYCPTGER1DHODH | |
| SCHEMBL121422 | 0.74 | HNF4A (0.63) | CD274L3MBTL1FABP4MYCPTGER1 | |
| SCHEMBL13504679 | 0.73 | HNF4A (0.50) | SYKL3MBTL1MYCPTGER1DHODH | |
| SCHEMBL15772646 | 0.71 | ACMSD (0.52) | SYKCD274L3MBTL1MYCPTGER1 | |
| SCHEMBL17158375 | 0.71 | PPARG (0.54) | CD274L3MBTL1PTGER1 | |
| SCHEMBL2556585 | 0.71 | NR1H4 (0.46) | SYKL3MBTL1 | |
| SCHEMBL5046158 | 0.70 | MYC (0.59) | L3MBTL1MYCPTGER1 | |
| SCHEMBL2559209 | 0.70 | TRIM24 (0.53) | SYKL3MBTL1MYCPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087943-B1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| US-6251925-B1 | AN AGONISTS FOR HUMAN BETA-3 ADRENOCEPTOR | GLAXO WELLCOME INC. | 2001-06-26 | — | — | US | disclosed |
| EP-1087943-A1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065877-A1 | THERAPEUTIC BIARYL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-12-23 | — | — | WO | disclosed |