SCHEMBL6437281

SCHEMBL6437281

NC(=S)c1cccc(Cn2c(C(=O)O)c(NC(=S)NCc3ccccc3)c3c(O)cccc32)c1

nearest known ligand 0.48

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
F10 P00742 13/20 0.48
RAB9A P51151 1/20 0.45
FOLH1 Q04609 3/20 0.43
F2 P00734 6/20 0.43
PLA2G10 O15496 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6432401 0.79 F10 (0.50) F10RAB9AFOLH1F2
Trifluoroacetic Acid SCHEMBL6436685 0.79 F10 (0.49) F10RAB9AFOLH1F2
Trifluoroacetic Acid SCHEMBL6432605 0.72 F10 (0.50) F10F2
SCHEMBL6437276 0.70 F10 (0.81) F10F2
SCHEMBL6433920 0.70 F10 (0.67) F10F2
SCHEMBL6432562 0.70 F10 (0.79) F10F2
SCHEMBL6435208 0.69 F10 (0.71) F10FOLH1F2PLA2G10
SCHEMBL7424420 0.69 F10 (0.73) F10F2
SCHEMBL27497454 0.67 PLA2G10 (0.74) F10F2PLA2G10
SCHEMBL6435201 0.67 F10 (0.81) F10FOLH1F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1042287-B1 INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA AVENTIS PHARMA GMBH (DE) 2005-04-20 EP disclosed
US-6337344-B1 ANTICOAGULANTS AND ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-01-08 US disclosed