Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 5/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.45 |
| ▸ | KLK1 | P06870 | 6/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | F11 | P03951 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6439089 | 0.82 | F2 (0.50) | F2PRSS1KLKB1 | |
| SCHEMBL7708347 | 0.79 | KLKB1 (0.41) | F2PRSS1KLKB1KLK1MAP4K1 | |
| SCHEMBL6437958 | 0.77 | F2 (0.53) | F2PRSS1KLKB1KLK1F11 | |
| SCHEMBL6252653 | 0.76 | MMP1 (0.51) | MMP1MMP3 | |
| Hydrochloric Acid SCHEMBL6441358 | 0.74 | F2 (0.51) | F2PRSS1 | |
| SCHEMBL21529121 | 0.74 | MMP8 (0.49) | MMP1MMP3 | |
| SCHEMBL21529123 | 0.74 | MMP8 (0.49) | MMP1MMP3 | |
| Hydrochloric Acid SCHEMBL6439707 | 0.73 | F2 (0.54) | F2PRSS1ROCK1 | |
| Naphthalene SCHEMBL6438601 | 0.73 | F2 (0.47) | F2PRSS1KLKB1KLK1ROCK1 | |
| SCHEMBL7431443 | 0.73 | KLKB1 (0.44) | KLKB1KLK1MAP4K1ROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1505062-A1 | Heterocyclic derivatives and their use as antithrombotic agents | Akzo Nobel N.V. (NL) | 2005-02-09 | — | — | EP | disclosed |
| US-6797710-B2 | CARDIOVASCULAR DISORDERS; SERINE PROTEASE INHIBITOR; ADMINISTERING BY MOUTH; BIOAVAILABILITY | AKZO NOBEL N.V. (NL) | 2004-09-28 | — | — | US | disclosed |
| US-20030130270-A1 | Heterocyclic derivatives and their use as antithrombotic agents | MERCK SHARP & DOHME B.V. (NL) | 2003-07-10 | — | — | US | disclosed |
| US-6432955-B1 | ANTICOAGULANTS | AKZO NOBEL N.V. (NL) | 2002-08-13 | — | — | US | disclosed |
| US-6194409-B1 | SERINE PROTEASE INHIBITOR; BIOAVAILABILITY WHEN ADMINISTERED BY MOUTH | AKZO NOBEL N.V. (NL) | 2001-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130270-A1 | Heterocyclic derivatives and their use as antithrombotic agents | F2, F12, VKORC1 | F2 1/4885PRSS1 857/4885KLKB1 2515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.