Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6415762 | 0.94 | KMT2A (0.64) | KMT2AMEN1TDP1KDM4EPOLB | |
| SCHEMBL6411491 | 0.87 | KMT2A (0.61) | KMT2AMEN1TDP1KDM4EPOLB | |
| SCHEMBL6410191 | 0.84 | POLB (0.53) | KMT2AMEN1TDP1KDM4EPOLB | |
| SCHEMBL6412185 | 0.84 | KMT2A (0.55) | KMT2AMEN1TDP1KDM4ETSHR | |
| SCHEMBL2402740 | 0.81 | KMT2A (0.66) | KMT2AMEN1TDP1KDM4EPOLB | |
| SCHEMBL6410679 | 0.81 | KMT2A (0.53) | KMT2AMEN1TDP1KDM4ETSHR | |
| SCHEMBL6411430 | 0.78 | RAB9A (0.47) | KMT2AMEN1TDP1KDM4EPOLB | |
| SCHEMBL6409627 | 0.77 | HPGD (0.40) | ALDH1A1 | |
| SCHEMBL6416570 | 0.76 | PKM (0.47) | KMT2AMEN1KDM4EPOLBALDH1A1 | |
| SCHEMBL2400990 | 0.76 | POLB (0.57) | KMT2AMEN1TDP1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |