Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | COMT | P21964 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1525815 | 0.78 | SLC6A2 (0.45) | — | |
| SCHEMBL29724050 | 0.78 | SLC6A2 (0.45) | — | |
| SCHEMBL8754632 | 0.78 | L3MBTL1 (0.39) | EGFRNOTUMMGLLCYP17A1 | |
| SCHEMBL3714790 | 0.73 | PLAU (0.41) | EGFRPLAUFDPSNOTUMF11 | |
| SCHEMBL30559520 | 0.73 | PLAU (0.43) | EGFRPLAUFDPSNOTUMPIK3CA | |
| SCHEMBL28323532 | 0.73 | EGFR (0.49) | EGFRPLAUFDPSNOTUMPIK3CA | |
| SCHEMBL2737364 | 0.73 | PLAU (0.43) | EGFRPLAUFDPSNOTUMF11 | |
| SCHEMBL27349333 | 0.72 | PTGS2 (0.43) | EGFRCOMTMGLLPTGS2CTSA | |
| SCHEMBL12915284 | 0.70 | PLAU (0.41) | EGFRPLAUFDPSNOTUMF11 | |
| SCHEMBL22166443 | 0.69 | PLAU (0.40) | PLAUFDPSNOTUMF11PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005024058-A2 | COMPOUNDS FOR THE TREATMENT OF DISEASES INVOLVING COGNITIVE IMPAIRMENT, SUCH AS ALZHEIMER’S DISEASE, AND METHODS FOR IDENTIFYING SUCH COMPOUNDS | GALAPAGOS N.V. (BE) | 2005-03-17 | — | — | WO | claimed |