Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL836172 | 0.82 | HSD11B1 (0.42) | PSIP1TDP1ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL12750891 | 0.78 | HSD11B1 (0.48) | ALDH1A1HSD17B10SMN1; SMN2HSD11B1TSHR | |
| SCHEMBL487264 | 0.75 | ALDH1A1 (0.44) | PSIP1TDP1ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL486729 | 0.75 | ALDH1A1 (0.44) | PSIP1TDP1ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL835147 | 0.75 | ALDH1A1 (0.44) | PSIP1TDP1ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL9400083 | 0.73 | ALDH1A1 (0.54) | PSIP1TDP1ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL833215 | 0.70 | HSD11B1 (0.38) | PSIP1HSD11B1POLBNR1I2ABCB1 | |
| SCHEMBL24394627 | 0.68 | PSIP1 (0.44) | PSIP1ALDH1A1SMN1; SMN2HSD11B1POLB | |
| SCHEMBL9400175 | 0.68 | CA1 (0.42) | PSIP1TDP1ALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL9456286 | 0.68 | CA1 (0.42) | PSIP1TDP1ALDH1A1SMN1; SMN2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511725-A1 | 24-SULFOXIMINE VITAMIN D sb 3 /sb COMPOUNDS | Johns Hopkins University (US) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003106411-A1 | 24-SULFOXIMINE VITAMIN D3 COMPOUNDS | JOHNS HOPKINS UNIVERSITY (US) | 2003-12-24 | — | — | WO | disclosed |