Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | ALB | P02768 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29255229 | 0.88 | DHODH (0.45) | DHODHSLC7A5PDK2SYKFAAH | |
| SCHEMBL15564511 | 0.83 | AKR1C3 (0.51) | DHODHSLC7A5PDK2FAAHPTGS2 | |
| SCHEMBL4205169 | 0.82 | HPGD (0.52) | SLC7A5PDK2FAAHPTGS2HPGD | |
| SCHEMBL74878 | 0.81 | SLC7A5 (0.55) | SLC7A5PDK2HPGDALDH1A1KDM4E | |
| SCHEMBL30692683 | 0.81 | SLC7A5 (0.55) | SLC7A5PDK2HPGDALDH1A1KDM4E | |
| Methane SCHEMBL9085715 | 0.81 | HPGD (0.51) | SLC7A5PDK2FAAHPTGS2HPGD | |
| SCHEMBL1132657 | 0.80 | SYK (0.49) | DHODHSLC7A5PDK2SYKHPGD | |
| SCHEMBL3361035 | 0.79 | SLC7A5 (0.54) | DHODHSLC7A5PDK2SYKHPGD | |
| SCHEMBL7031826 | 0.78 | HTR7 (0.63) | SLC7A5 | |
| SCHEMBL29255156 | 0.77 | ALDH1A1 (0.51) | DHODHSLC7A5SYKHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050113331-A1 | Compositions and methods for use of antiviral drugs in the treatment of retroviral diseases resistant to nucleoside reverse transcriptase inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-05-26 | — | — | US | disclosed |
| WO-2005023270-A2 | COMPOSITIONS AND METHODS FOR USE OF ANTIVIRAL DRUGS IN THE TREATMENT OF RETROVIRAL DISEASES RESISTANT TO NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2005-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113331-A1 | Compositions and methods for use of antiviral drugs in the treatment of retroviral diseases resistant to nucleoside reverse transcriptase inhibitors | TYMP, TYMS, SAMHD1 | CNR1 4184/4885DHODH 196/4885SLC7A5 4168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.