Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16174112 | 0.87 | ABCB1 (0.51) | ABCB1PPARGPPARANPSR1CTSS | |
| SCHEMBL5860845 | 0.86 | ABCB1 (0.51) | ABCB1PPARGPPARANPSR1CTSS | |
| SCHEMBL6443317 | 0.86 | PPARA (0.48) | PPARGPPARACTSSCTSKCACNA1B | |
| SCHEMBL8912015 | 0.86 | PPARA (0.46) | PPARGPPARACTSSCTSKATM | |
| SCHEMBL12732987 | 0.86 | ABCB1 (0.53) | ABCB1PPARGPPARANPSR1CTSS | |
| SCHEMBL13363641 | 0.86 | CTSK (0.51) | PPARGPPARACTSSCTSKATM | |
| SCHEMBL335777 | 0.86 | CTSK (0.51) | PPARGPPARACTSSCTSKATM | |
| SCHEMBL12070284 | 0.86 | CTSK (0.51) | PPARGPPARACTSSCTSKATM | |
| SCHEMBL6166 | 0.86 | CTSK (0.51) | PPARGPPARACTSSCTSKATM | |
| SCHEMBL767076 | 0.86 | CTSK (0.51) | PPARGPPARACTSSCTSKATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050209177-A9 | Combined therapeutical treatment of hyperproliferative diseases | TOCQUE BRUNO | 2005-09-22 | — | — | US | disclosed |
| US-20040127437-A1 | Combined therapeutical treatment of hyperproliferative diseases | TOCQUE BRUNO (FR) | 2004-07-01 | — | — | US | disclosed |
| US-20010021395-A1 | Method for destroying hyperproliferative cells by combined p53 and taxoid treatment | TOCQUE BRUNO (FR) | 2001-09-13 | — | — | US | disclosed |
| US-6262032-B1 | WHEREIN THE ADENOVIRAL VECTOR AND THE TAXOID COMPOUND ARE BROUGHT INTO CONTACT WITH THE CELL SIMULTANEOUSLY. | AVENTIS PHARMA S.A. (FR) | 2001-07-17 | — | — | US | disclosed |
| US-5670536-A | Pharmaceutical composition based on taxoids | RHONE-POULENC RORER S.A. (FR) | 1997-09-23 | — | — | US | disclosed |
| US-5606068-A | Acid anhydrides, their preparation and their use | RHONE-POULENC RORER S.A. (FR) | 1997-02-25 | — | — | US | disclosed |
| US-5476954-A | Condensing hydroxyl protected taxane derivative with oxazolidine derivative, decyclizing in acid medium, reacting butoxycarbonyl or benzoyl radical with amine, deprotecting, isolating, purifying product | RHONE-POULENC RORER S.A. (FR) | 1995-12-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010021395-A1 | Method for destroying hyperproliferative cells by combined p53 and taxoid treatment | TP53, HRAS, MYC | ABCB1 2765/4885PPARG 2203/4885PPARA 2010/4885 |
| US-20050209177-A9 | Combined therapeutical treatment of hyperproliferative diseases | HRAS, MYC, TP53 | ABCB1 3347/4885PPARG 1273/4885PPARA 1170/4885 |
| US-20040127437-A1 | Combined therapeutical treatment of hyperproliferative diseases | HRAS, MYC, TP53 | ABCB1 3347/4885PPARG 1273/4885PPARA 1170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.