Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GABRP | O00591 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.46 |
| ▸ | GABRE | P78334 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.46 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.46 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethyl Isonipecotate SCHEMBL27886 | 1.00 | MAPT (0.51) | MAPTALDH1A1GABRPGABRDGABRA1 | |
| Ethyl Isonipecotate SCHEMBL1420351 | 0.98 | MAPT (0.50) | MAPTALDH1A1GABRPGABRDGABRA1 | |
| SCHEMBL3476143 | 0.93 | ALDH1A1 (0.51) | MAPTALDH1A1GABRPGABRDGABRA1 | |
| Ethyl Isonipecotate SCHEMBL27812954 | 0.91 | ALDH1A1 (0.46) | MAPTALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL15970872 | 0.91 | ALDH1A1 (0.50) | MAPTALDH1A1PKM | |
| Ethyl Isonipecotate SCHEMBL9733648 | 0.89 | MAPT (0.48) | MAPTALDH1A1TSHRPKM | |
| SCHEMBL12994147 | 0.88 | MAPT (0.49) | MAPTALDH1A1GABRPGABRDGABRA1 | |
| SCHEMBL8224141 | 0.88 | MAPT (0.49) | MAPTALDH1A1GABRPGABRDGABRA1 | |
| SCHEMBL2235927 | 0.88 | MAPT (0.49) | MAPTALDH1A1GABRPGABRDGABRA1 | |
| Ethyl Isonipecotate SCHEMBL20300378 | 0.88 | MAPT (0.43) | MAPTALDH1A1GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077942-B1 | CARBOXY SUBSTITUTED CARBOXAMIDE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | AVENTIS PHARMA INC (US) | 2005-01-12 | — | — | EP | disclosed |
| US-6316445-B1 | TACHYKININ RECEPTOR ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. | 2001-11-13 | — | — | US | disclosed |