Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29163117 | 0.85 | MEN1 (0.46) | ALDH1A1L3MBTL1LMNAKMT2AMEN1 | |
| SCHEMBL249552 | 0.85 | KMT2A (0.71) | ALDH1A1LMNAKMT2AMEN1THRB | |
| SCHEMBL31175932 | 0.85 | KMT2A (0.71) | ALDH1A1LMNAKMT2AMEN1THRB | |
| SCHEMBL27511393 | 0.83 | KMT2A (0.67) | ALDH1A1LMNAKMT2AMEN1THRB | |
| SCHEMBL31588841 | 0.83 | KMT2A (0.67) | ALDH1A1LMNAKMT2AMEN1THRB | |
| SCHEMBL18605410 | 0.82 | MEN1 (0.43) | ALDH1A1L3MBTL1LMNAKMT2AMEN1 | |
| SCHEMBL6571919 | 0.82 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1LMNAKMT2AMEN1 | |
| SCHEMBL3880759 | 0.81 | ADORA2A (0.47) | ALDH1A1L3MBTL1LMNAKMT2AMEN1 | |
| SCHEMBL29365160 | 0.80 | — | — | |
| SCHEMBL29776700 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103224436-B | The preparation method of the amino diaryl ketone compound of a kind of neighbour | WENZHOU UNIVERSITY (CN) | 2015-09-02 | — | — | CN | disclosed |
| US-8119630-B2 | Benzodiazepine derivatives and pharmaceutical compositions containing them | ARROW THERAPEUTICS LIMITED (GB) | 2012-02-21 | — | — | US | disclosed |
| CN-1694874-B | Benzodiazepine derivatives and pharmaceutical compositions containing them | ARROW THERAPEUTICS LTD | 2010-06-09 | — | — | CN | disclosed |
| US-20100015063-A1 | Benzodiazepine Derivatives and Pharmaceutical Compositions Containing Them | ARROW THERAPEUTICS LIMITED (GB) | 2010-01-21 | — | — | US | disclosed |
| US-7582624-B2 | Benzodiazepine derivatives and pharmaceutical compositions containing them | ARROW THERAPEUTICS LIMITED (GB) | 2009-09-01 | — | — | US | disclosed |
| US-20060040923-A1 | Benzodiazepine derivatives and pharmaceutical compositions containing them | ARROW THERAPEUTICS LIMITED (GB) | 2006-02-23 | — | — | US | disclosed |
| CN-1694874-A | Benzodiazepine * derivatives and pharmaceutical compositions containing them | ARROW THERAPEUTICS LTD (GB) | 2005-11-09 | — | — | CN | disclosed |
| EP-1539716-A1 | BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Arrow Therapeutics Limited (GB) | 2005-06-15 | — | — | EP | disclosed |
| CN-1195757-C | Optically pure camptothecin analogues | SOD CONSEILS RECH APPLIC (FR) | 2005-04-06 | — | — | CN | disclosed |
| WO-2004026843-A1 | BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ARROW THERAPEUTICS LIMITED (GB) | 2004-04-01 | — | — | WO | disclosed |
| CN-1345321-A | Optically pure camptothecin analogs | SOD CONSEILS RECH APPLIC (FR) | 2002-04-17 | — | — | CN | disclosed |
| WO-2000014073-A1 | BENZODIAZEPINONE DERIVATIVES, PREPARATION METHOD AND INTERMEDIATES THEREFOR, USE AS MEDICINES AND COMPOSITIONS | HOECHST MARION ROUSSEL (FR) | 2000-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040923-A1 | Benzodiazepine derivatives and pharmaceutical compositions containing them | GABRA6, CNR1, SIGMAR1 | ALDH1A1 2127/4885L3MBTL1 2764/4885LMNA 1425/4885 |
| US-20100015063-A1 | Benzodiazepine Derivatives and Pharmaceutical Compositions Containing Them | GABRA6, CNR1, SIGMAR1 | ALDH1A1 1931/4885L3MBTL1 2763/4885LMNA 1262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.