SCHEMBL6440045

SCHEMBL6440045

CCOCc1nc2nccnc2c(=O)[nH]1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 14/20 0.43
CDC7 O00311 1/20 0.39
CCNE1 P24864 1/20 0.39
CDK2 P24941 1/20 0.39
ROCK1 Q13464 1/20 0.39
DBF4 Q9UBU7 1/20 0.39
RAB9A P51151 2/20 0.33
ALDH1A1 P00352 2/20 0.33
NPC1 O15118 1/20 0.33
HTT P42858 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
GAA P10253 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9196894 0.91 HCAR2 (0.38) HCAR2CDC7CCNE1CDK2ROCK1
SCHEMBL9191469 0.90 HCAR2 (0.47) HCAR2RAB9AALDH1A1NPC1L3MBTL1
SCHEMBL9194026 0.85 HCAR2 (0.44) HCAR2CCNE1CDK2RAB9AALDH1A1
SCHEMBL9190029 0.84 ALDH1A1 (0.43) HCAR2CCNE1CDK2ALDH1A1
SCHEMBL3817859 0.82 TNKS2 (0.44) HCAR2ALDH1A1L3MBTL1
SCHEMBL9197478 0.81 ALDH1A1 (0.45) HCAR2CDC7CCNE1CDK2ROCK1
SCHEMBL9191459 0.81 HCAR2 (0.40) HCAR2RAB9AALDH1A1
SCHEMBL9195013 0.81 HCAR2 (0.37) HCAR2RAB9A
SCHEMBL9194269 0.80 HCAR2 (0.33) HCAR2CDC7CCNE1CDK2ROCK1
SCHEMBL9194837 0.80 CDC7 (0.38) HCAR2CDC7CCNE1CDK2ROCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1041972-B1 TABLET FOR INSTANT AND PROLONGED RELEASE OF ONE OR MORE ACTIVE SUBSTANCES MERCK PATENT GMBH (DE) 2002-09-04 EP claimed
US-6372255-B1 Tablet for instant and prolonged release of one or more active substances MERCK PATENT GESELLSCHAFT (DE) 2002-04-16 US claimed
EP-1041972-A1 TABLET FOR INSTANT AND PROLONGED RELEASE OF ONE OR MORE ACTIVE SUBSTANCES MERCK PATENT GmbH (DE) 2000-10-11 EP claimed
WO-1999033448-A1 TABLET FOR INSTANT AND PROLONGED RELEASE OF ONE OR MORE ACTIVE SUBSTANCES MERCK PATENT GMBH (DE) 1999-07-08 WO claimed
EP-0399856-B1 Pteridin-4 (3H)-ones, processes for their preparation and medicaments containing them LIPHA (FR) 1995-08-09 EP claimed
US-5270465-A 4(3H)-pteridinone compounds LIPHA, LYONNAISE INDUSTRILLE PHARMACEUTIQUE (FR) 1993-12-14 US claimed
US-5167949-A Antiallergic LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) 1992-12-01 US claimed
EP-0399856-A1 Pteridin-4 (3H)-ones, processes for their preparation and medicaments containing them LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) 1990-11-28 EP claimed
US-20050222193-A1 Novel combination for the treatment of airway disorders ALTANA PHARMA AG (DE) 2005-10-06 US disclosed
WO-2005074932-A1 THE USE OF (S) - PANTOPRAZOLE MAGNESIUM FOR THE TREATMENT OF AIRWAY DISORDERS ALTANA PHARMA AG (DE) 2005-08-18 WO disclosed
US-20050165041-A1 Combination for the treatment of airway disorders ALTANA PHARMA AG (DE) 2005-07-28 US disclosed
EP-1517706-A2 COMBINATION OF A PROTON PUMP INHIBITOR AND A RESPIRATORY AGENT FOR THE TREATMENT OF RESPIRATORY DISEASES ALTANA Pharma AG (DE) 2005-03-30 EP disclosed
EP-1506016-A2 NEW COMBINATION OF REVERSIBLE PROTON PUMP INHIBITORS AND AIRWAY THERAPEUTICS FOR TREATING AIRWAY DISORDERS ALTANA Pharma AG (DE) 2005-02-16 EP disclosed
WO-2003094968-A2 COMBINATION OF A PROTON PUMP INHIBITOR AND A RESPIRATORY AGENT FOR THE TREATMENT OF RESPIRATORY DISEASES ALTANA PHARMA AG (DE) 2003-11-20 WO disclosed
EP-1041972-A1 TABLET FOR INSTANT AND PROLONGED RELEASE OF ONE OR MORE ACTIVE SUBSTANCES MERCK PATENT GmbH (DE) 2000-10-11 EP disclosed
WO-1999033448-A1 TABLET FOR INSTANT AND PROLONGED RELEASE OF ONE OR MORE ACTIVE SUBSTANCES MERCK PATENT GMBH (DE) 1999-07-08 WO disclosed
EP-0399856-B1 Pteridin-4 (3H)-ones, processes for their preparation and medicaments containing them LIPHA (FR) 1995-08-09 EP disclosed
US-5270465-A 4(3H)-pteridinone compounds LIPHA, LYONNAISE INDUSTRILLE PHARMACEUTIQUE (FR) 1993-12-14 US disclosed
US-5167949-A Antiallergic LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) 1992-12-01 US disclosed
EP-0399856-A1 Pteridin-4 (3H)-ones, processes for their preparation and medicaments containing them LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) 1990-11-28 EP disclosed