Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 13/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9191397 | 0.90 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2HCAR2CCNE1CDK2 | |
| SCHEMBL9194026 | 0.88 | HCAR2 (0.44) | ALDH1A1SMN1; SMN2HCAR2CCNE1CDK2 | |
| SCHEMBL6440045 | 0.84 | HCAR2 (0.43) | ALDH1A1HCAR2CCNE1CDK2 | |
| SCHEMBL9195013 | 0.83 | HCAR2 (0.37) | HCAR2PDE1APDE1BPDE1C | |
| SCHEMBL9191469 | 0.83 | HCAR2 (0.47) | ALDH1A1HCAR2PDE2APDE1APDE1B | |
| SCHEMBL9191276 | 0.83 | HCAR2 (0.51) | ALDH1A1SMN1; SMN2HCAR2 | |
| SCHEMBL3817859 | 0.81 | TNKS2 (0.44) | ALDH1A1SMN1; SMN2HCAR2 | |
| SCHEMBL9195100 | 0.79 | RAB9A (0.59) | SMN1; SMN2HCAR2 | |
| SCHEMBL9191459 | 0.78 | HCAR2 (0.40) | ALDH1A1HCAR2 | |
| SCHEMBL9189988 | 0.77 | HCAR2 (0.56) | HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399856-B1 | Pteridin-4 (3H)-ones, processes for their preparation and medicaments containing them | LIPHA (FR) | 1995-08-09 | — | — | EP | claimed |
| US-5270465-A | 4(3H)-pteridinone compounds | LIPHA, LYONNAISE INDUSTRILLE PHARMACEUTIQUE (FR) | 1993-12-14 | — | — | US | claimed |
| US-5167949-A | Antiallergic | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1992-12-01 | — | — | US | claimed |
| EP-0399856-A1 | Pteridin-4 (3H)-ones, processes for their preparation and medicaments containing them | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1990-11-28 | — | — | EP | claimed |
| JP-2304089-A | — | — | None | — | — | JP | disclosed |
| EP-0399856-B1 | Pteridin-4 (3H)-ones, processes for their preparation and medicaments containing them | LIPHA (FR) | 1995-08-09 | — | — | EP | disclosed |
| US-5270465-A | 4(3H)-pteridinone compounds | LIPHA, LYONNAISE INDUSTRILLE PHARMACEUTIQUE (FR) | 1993-12-14 | — | — | US | disclosed |
| US-5167949-A | Antiallergic | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1992-12-01 | — | — | US | disclosed |
| JP-H02304089-A | 4(3H)-PTERIDINONE, ITS PRODUCTION, ANTIALLERGIC AGENT AND BRONCHOCONSTRICTION PREVENTIVE | LIPHA (LYON IND PHARMACEUT) | 1990-12-17 | — | — | JP | disclosed |
| EP-0399856-A1 | Pteridin-4 (3H)-ones, processes for their preparation and medicaments containing them | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1990-11-28 | — | — | EP | disclosed |