SCHEMBL6440064

SCHEMBL6440064

CC(C)(CO)NC(=O)c1ncc(Br)cn1

nearest known ligand 0.40

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 16/20 0.40
CNR1 P21554 15/20 0.40
FPR3 P25089 1/20 0.40
FPR2 P25090 1/20 0.40
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
ATM Q13315 1/20 0.38
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2538917 0.82 NPC1 (0.41) NPC1RAB9AKMT2A
SCHEMBL6415380 0.81 CNR2 (0.52) CNR2CNR1NPC1RAB9AATM
SCHEMBL17841457 0.80 CNR2 (0.51) CNR2CNR1KMT2A
SCHEMBL13555791 0.77 GRM5 (0.40) CNR2CNR1NPC1RAB9AATM
SCHEMBL22558685 0.76 MAP4K4 (0.39) CNR2CNR1NPC1RAB9AATM
SCHEMBL6419777 0.75 CNR2 (0.40) CNR2CNR1NPC1RAB9AATM
SCHEMBL13388126 0.75 ADORA2A (0.40) CNR2CNR1NPC1RAB9A
SCHEMBL4240834 0.72 OGG1 (0.53) NPC1RAB9AATMKMT2A
SCHEMBL658490 0.72 CREBBP (0.41) CNR1NPC1RAB9AKMT2A
SCHEMBL930305 0.72 P2RX7 (0.59) NPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6936736-B2 Amide derivative SUMITOMO MANUFACTURING COMPANY LIMITED (JP) 2005-08-30 US disclosed
US-20020147204-A1 Amide derivative SUMITOMO PHARMACEUTICALS COMPANY, LIMITED 2002-10-10 US disclosed
US-6384033-B1 DRUGS FOR VISION DEFECTS SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2002-05-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020147204-A1 Amide derivative ALDH1A2, NR1H2, HDAC3 CNR2 183/4885CNR1 206/4885FPR3 1909/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.