Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 18/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 17/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6444686 | 0.88 | RAB9A (0.42) | P2RX3P2RX2KMT2A | |
| SCHEMBL5041750 | 0.85 | ADORA2A (0.44) | ADORA1ADORA2AADORA2BP2RX3P2RX2 | |
| SCHEMBL6444797 | 0.83 | P2RX3 (0.40) | ADORA1ADORA2AP2RX3P2RX2KMT2A | |
| SCHEMBL6443503 | 0.81 | P2RX3 (0.38) | P2RX3P2RX2KMT2A | |
| SCHEMBL6442124 | 0.80 | P2RX3 (0.41) | ADORA2AP2RX3P2RX2KMT2A | |
| SCHEMBL6443545 | 0.74 | ADORA1 (0.63) | ADORA1ADORA2AADORA2B | |
| SCHEMBL6446153 | 0.71 | ADORA2A (0.38) | ADORA1ADORA2AADORA2BP2RX3P2RX2 | |
| SCHEMBL6441739 | 0.69 | ADORA1 (0.61) | ADORA1ADORA2AADORA2B | |
| SCHEMBL6444939 | 0.69 | APP (0.53) | — | |
| SCHEMBL6443028 | 0.68 | ADORA1 (0.60) | ADORA1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261327-B1 | ADENOSINE RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2005-04-27 | — | — | EP | disclosed |
| EP-1261327-A2 | ADENOSINE RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001062233-A2 | ADENOSINE RECEPTOR MODULATORS | F. HOFFMANN LA ROCHE AG (CH) | 2001-08-30 | — | — | WO | disclosed |