Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.48 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487789 | 1.00 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL644069 | 1.00 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL644623 | 0.88 | OPRM1 (0.42) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL2489076 | 0.88 | OPRM1 (0.42) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL644622 | 0.88 | OPRM1 (0.42) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL645187 | 0.81 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL644006 | 0.78 | OPRM1 (0.51) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL643066 | 0.77 | OPRM1 (0.50) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL7054929 | 0.77 | OPRM1 (0.63) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL493456 | 0.76 | OPRM1 (0.51) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119633-B2 | N-{2-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-2-oxo-ethoxy]-ethyl}-N-ethyl-4-methoxy-2,3,6-trimethyl-phenylsulfonamide; condensing the N-carboxyalkyl phenylsulfonamide with the substituted piperidine; bradykinin receptor antagonists; analgesics; antidiabetics; angiogenesis inhibitors; rheumatic diseases | GRUENENTHAL GMBH (DE) | 2012-02-21 | — | — | US | disclosed |
| EP-2150530-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2150530-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-02-10 | — | — | EP | disclosed |
| US-20080312231-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-18 | — | — | US | disclosed |
| WO-2008131947-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312231-A1 | Substituted Sulfonamide Compounds | SULT2A1, SULT1A1, SCN1A | OPRM1 91/4885OPRD1 61/4885OPRK1 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.