Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11027264 | 0.82 | GAA (0.48) | GAAMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL27520395 | 0.77 | MEN1 (0.44) | GAAMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL22610224 | 0.74 | CYP2C19 (0.47) | GAAMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL8203981 | 0.74 | L3MBTL1 (0.46) | GAAMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL8192518 | 0.74 | L3MBTL1 (0.46) | GAAMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL4938951 | 0.73 | CYP2C19 (0.46) | GAAMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL16118686 | 0.73 | HSD17B10 (0.49) | TSHRL3MBTL1TDP1ALDH1A1HSD17B10 | |
| SCHEMBL7545279 | 0.73 | SMN1; SMN2 (0.43) | GAAMEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL18248588 | 0.72 | CYP2C19 (0.45) | GAAMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL18248622 | 0.72 | CYP2C19 (0.45) | GAAMEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501807-A1 | SULFONYLQUINOXALONE ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ ANTAGONISTS | Elan Pharmaceuticals, Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093245-A1 | SULFONYLQUINOXALONE ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ ANTAGONISTS | ELAN PHARMACEUTICALS, INC. (US) | 2003-11-13 | — | — | WO | disclosed |