SCHEMBL6440830

SCHEMBL6440830

CC(C)(C)[Si](C)(C)OC1=CCc2ccccc21

nearest known ligand 0.35

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 1/20 0.31
BCHE P06276 1/20 0.31
PREP P48147 1/20 0.31
HSP90AA1 P07900 1/20 0.30
HSP90AB1 P08238 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7614983 0.82 HTR6 (0.34) HTR6
SCHEMBL7034170 0.81
SCHEMBL29341169 0.80 APLNR (0.34)
SCHEMBL30666585 0.80 ADORA1 (0.32) PREP
SCHEMBL29060208 0.76 NPC1 (0.32)
SCHEMBL30695752 0.76
SCHEMBL30008167 0.76 NPC1 (0.32)
SCHEMBL5154215 0.76
SCHEMBL17460765 0.75
SCHEMBL6909323 0.72 CDC25A (0.38) HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190119420-A1 CATALYST COMPOSITION FOR SYNTHESIZING OLEFIN COPOLYMER AND METHOD FOR PREPARING OLEFIN COPOLYMER LG CHEM, LTD. (KR) 2019-04-25 US disclosed
US-20170283522-A1 METALLOCENE COMPOUND, METALLOCENE-SUPPORTED CATALYST, AND METHOD OF PREPARING POLYOLEFIN USING THE SAME LG CHEM, LTD. (KR) 2017-10-05 US disclosed
US-20170283522-A1 METALLOCENE COMPOUND, METALLOCENE-SUPPORTED CATALYST, AND METHOD OF PREPARING POLYOLEFIN USING THE SAME LG CHEM, LTD. (KR) 2017-10-05 US disclosed
EP-0975644-B1 SUBSTITUTED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION CATALYST SYSTEMS, THEIR INTERMEDIATES AND METHODS FOR PREPARING THEM BOREALIS TECH OY (FI) 2005-03-16 EP disclosed
US-6355819-B1 TRANSITION METAL METALLOCENES WITH HETEROATOM 1- OR 3-SUBSTITUTED INDENYL AND INDENYL DERIVATIVE LIGANDS BOREALIS TECHNOLOGY OY (FI) 2002-03-12 US disclosed
EP-0975644-A1 SUBSTITUTED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION CATALYST SYSTEMS, THEIR INTERMEDIATES AND METHODS FOR PREPARING THEM BOREALIS A/S (DK) 2000-02-02 EP disclosed
WO-1998046616-A1 SUBSTITUTED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION CATALYST SYSTEMS, THEIR INTERMEDIATES AND METHODS FOR PREPARING THEM BOREALIS A/S (DK) 1998-10-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170283522-A1 METALLOCENE COMPOUND, METALLOCENE-SUPPORTED CATALYST, AND METHOD OF PREPARING POLYOLEFIN USING THE SAME PCBP1, POLA1, POLI HTR6 4096/4885BCHE 3724/4885PREP 2822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.