Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.81 |
| ▸ | MME | P08473 | 2/20 | 0.81 |
| ▸ | NPPA | P01160 | 1/20 | 0.81 |
| ▸ | ECE1 | P42892 | 1/20 | 0.81 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | NPY4R | P50391 | 1/20 | 0.42 |
| ▸ | GNPAT | O15228 | 1/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.41 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.41 |
| ▸ | CHRND | Q07001 | 5/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.41 |
| ▸ | CHRNG | P07510 | 1/20 | 0.41 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295371 | 0.91 | MME (0.68) | ACEMMENPPAECE1ITGB3 | |
| Sampatrilat SCHEMBL7301333 | 0.90 | ECE1 (1.00) | ACEMMENPPAECE1ITGB3 | |
| Sampatrilat SCHEMBL4567110 | 0.90 | ECE1 (1.00) | ACEMMENPPAECE1ITGB3 | |
| Sampatrilat SCHEMBL49066 | 0.90 | ECE1 (1.00) | ACEMMENPPAECE1ITGB3 | |
| SCHEMBL7293852 | 0.89 | MME (0.77) | ACEMMENPPAECE1NPY1R | |
| SCHEMBL7293844 | 0.89 | MME (0.77) | ACEMMENPPAECE1NPY1R | |
| SCHEMBL7293863 | 0.89 | MME (0.77) | ACEMMENPPAECE1NPY1R | |
| SCHEMBL7300825 | 0.87 | MME (0.71) | ACEMMENPPAECE1GRIA1 | |
| SCHEMBL7300818 | 0.87 | MME (0.71) | ACEMMENPPAECE1GRIA1 | |
| SCHEMBL7302871 | 0.86 | MME (0.82) | ACEMMENPPAECE1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050070543-A1 | Compositions of a chromene or phenyl acetic acid cyclooxygenase-2 selective inhibitor and an ACE inhibitor for the treatment of central nervous system damage | PHARMACIA CORPORATION | 2005-03-31 | — | — | US | claimed |
| WO-2005016249-A2 | COMPOSITIONS OF A CHROMENE OR PHENYL ACETIC ACID CYCLOOXYGENASE-2 SELECTIVE INHIBITOR AND AN ACE INHIBITOR FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DAMAGE | PHARMACIA CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070543-A1 | Compositions of a chromene or phenyl acetic acid cyclooxygenase-2 selective inhibitor and an ACE inhibitor for the treatment of central nervous system damage | ACE, ACE2, AGTR2 | ACE 1/4885MME 76/4885NPPA 1649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.