Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 3/20 | 0.77 |
| ▸ | ACE | P12821 | 2/20 | 0.77 |
| ▸ | ECE1 | P42892 | 2/20 | 0.77 |
| ▸ | NPPA | P01160 | 1/20 | 0.77 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | NPY4R | P50391 | 1/20 | 0.44 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | NTSR2 | O95665 | 2/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293863 | 1.00 | MME (0.77) | MMEACEECE1NPPAMMP2 | |
| SCHEMBL7293852 | 1.00 | MME (0.77) | MMEACEECE1NPPAMMP2 | |
| SCHEMBL6441043 | 0.89 | ACE (0.81) | MMEACEECE1NPPANPY1R | |
| SCHEMBL9367724 | 0.88 | MME (0.71) | MMEACEECE1NPPAITGB1 | |
| SCHEMBL9367717 | 0.88 | MME (0.71) | MMEACEECE1NPPAITGB1 | |
| SCHEMBL9367712 | 0.88 | MME (0.71) | MMEACEECE1NPPAITGB1 | |
| Sampatrilat SCHEMBL4567110 | 0.87 | ECE1 (1.00) | MMEACEECE1NPPAITGB1 | |
| Sampatrilat SCHEMBL7301333 | 0.87 | ECE1 (1.00) | MMEACEECE1NPPAITGB1 | |
| Sampatrilat SCHEMBL49066 | 0.87 | ECE1 (1.00) | MMEACEECE1NPPAITGB1 | |
| SCHEMBL7300557 | 0.85 | MME (0.78) | MMEACEECE1NPPAERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0358398-B1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS | Pfizer Limited (GB) | 1993-03-10 | — | — | EP | claimed |
| EP-0358398-A1 | Cycloalkyl-substituted glutaramide antihypertensive agents | Pfizer Limited (GB) | 1990-03-14 | — | — | EP | claimed |
| JP-2124862-A | — | — | None | — | — | JP | disclosed |
| EP-0358398-B1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS | Pfizer Limited (GB) | 1993-03-10 | — | — | EP | disclosed |
| US-4975444-A | INHIBITORS OF ANGIORENSIN-CONVERTING ENZYME AS WELL AS A ENDOPEPTIDASE; CARDIOTONIC AGENTS; GLAUCOMA; DIURETICS | PFIZER INC. (US) | 1990-12-04 | — | — | US | disclosed |
| JP-H02124862-A | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENT | PFIZER INC | 1990-05-14 | — | — | JP | disclosed |
| EP-0358398-A1 | Cycloalkyl-substituted glutaramide antihypertensive agents | Pfizer Limited (GB) | 1990-03-14 | — | — | EP | disclosed |