Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.50 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.50 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.50 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.50 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR1E | P28566 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3800552 | 0.83 | HTR2A (0.55) | HTR2AADRB1HTR1AADRA2ASLC6A2 | |
| SCHEMBL3799963 | 0.83 | HTR2A (0.55) | HTR2AADRB1HTR1AADRA2ASLC6A2 | |
| SCHEMBL27469772 | 0.79 | SSTR1 (0.54) | HTR2AADRB1HTR1AADRA2ASLC6A2 | |
| SCHEMBL27469773 | 0.79 | SSTR1 (0.54) | HTR2AADRB1HTR1AADRA2ASLC6A2 | |
| SCHEMBL27564454 | 0.79 | HTR2A (0.55) | HTR2AADRB1HTR1AADRA2ASLC6A2 | |
| SCHEMBL1926338 | 0.79 | HTR2A (0.55) | HTR2AADRB1HTR1AADRA2ASLC6A2 | |
| Hydrochloric Acid SCHEMBL27548729 | 0.78 | SSTR1 (0.53) | HTR2AADRB1HTR1AADRA2ASLC6A2 | |
| Hydrochloric Acid SCHEMBL6715553 | 0.78 | SSTR1 (0.53) | HTR2AADRB1HTR1AADRA2ASLC6A2 | |
| Bromide SCHEMBL6441072 | 0.77 | MEN1 (0.47) | HTR2ASLC6A2HTR2CSLC6A4HTR2B | |
| SCHEMBL7563868 | 0.71 | GHSR (0.46) | HTR2AADRB1HTR1AADRA2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1555264-A1 | Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase. | Sireen AG (DE) | 2005-07-20 | — | — | EP | disclosed |