Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CCR4 | P51679 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6441067 | 0.77 | HTR2A (0.50) | MEN1KMT2AMAPTALDH1A1TDP1 | |
| SCHEMBL6823826 | 0.74 | MEN1 (0.70) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL13253129 | 0.70 | MEN1 (0.74) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7015690 | 0.70 | MEN1 (0.73) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL19973935 | 0.69 | MGAM (0.65) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL274662 | 0.66 | HTR2A (1.00) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL29611535 | 0.66 | HTR2A (1.00) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7005714 | 0.65 | GPR84 (1.00) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7011743 | 0.64 | MEN1 (0.64) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7006159 | 0.64 | NR3C1 (0.69) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1555264-A1 | Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase. | Sireen AG (DE) | 2005-07-20 | — | — | EP | disclosed |