Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6035723 | 0.82 | CDK1 (0.44) | SIGMAR1TMEM97HTTMAP2K2MAP2K1 | |
| SCHEMBL6035363 | 0.82 | MAP2K1 (0.64) | MAP2K2MAP2K1 | |
| SCHEMBL6438484 | 0.78 | MAP2K1 (0.47) | MAP2K2MAP2K1KDM4EALDH1A1HPGD | |
| SCHEMBL6035714 | 0.78 | MEN1 (0.47) | HTTMAP2K2MAP2K1KDM4EALDH1A1 | |
| SCHEMBL6035643 | 0.78 | ALDH1A1 (0.60) | SIGMAR1TMEM97HTTMAP2K2MAP2K1 | |
| SCHEMBL27583296 | 0.76 | MAP2K1 (0.61) | PTGS2MAP2K2MAP2K1SMN1; SMN2 | |
| SCHEMBL6036426 | 0.75 | MAPT (0.41) | SIGMAR1TMEM97HTTMAP2K2MAP2K1 | |
| SCHEMBL27592276 | 0.75 | MAP2K1 (0.52) | MAP2K2MAP2K1 | |
| SCHEMBL6951788 | 0.74 | MAP2K2 (0.46) | MAP2K2MAP2K1KDM4EALDH1A1HPGD | |
| SCHEMBL6036183 | 0.73 | ALDH1A1 (0.46) | SIGMAR1TMEM97HTTMAP2K2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140291-B1 | COMBINATION CHEMOTHERAPY COMPRISING A MITOTIC INHIBITOR AND A MEK INHIBITOR | WARNER LAMBERT CO (US) | 2005-11-23 | — | — | EP | disclosed |