Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL701889 | 0.93 | TSHR (0.32) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL12095053 | 0.93 | TSHR (0.32) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Bicarbonate SCHEMBL6439508 | 0.86 | — | — | |
| SCHEMBL29043273 | 0.78 | ALDH1A1 (0.48) | — | |
| SCHEMBL6439504 | 0.77 | — | — | |
| SCHEMBL16754719 | 0.76 | TSHR (0.31) | — | |
| SCHEMBL12095052 | 0.75 | RORC (0.34) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL701888 | 0.75 | RORC (0.34) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL17322700 | 0.74 | GABRA1 (0.31) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL700476 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823744-B1 | Ionically conductive polymeric gel electrolyte and solid battery containing the same | MITSUI CHEMICALS INC (JP) | 2005-10-12 | — | — | EP | disclosed |
| US-5925283-A | HIGH IONIC CONDUCTIVITY AND HIGH SOLID STRENGTH; CROSSLINKED POLYMER MATRIX, ELECTROLYTIC SALT, AND A NONAQUEOUS ELECTROLYTIC SOLUTION WHICH CONTAINS AT LEAST ONE HALOGEN-SUBSTITUTED CARBONIC ESTER | MITSUI CHEMICALS, INC. (JP) | 1999-07-20 | — | — | US | disclosed |
| EP-0823744-A2 | Ionically conductive polymeric gel electrolyte and solid battery containing the same | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-11 | — | — | EP | disclosed |