Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646013 | 0.86 | SIGMAR1 (0.41) | SIGMAR1ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL493031 | 0.85 | POLB (0.41) | POLBSIGMAR1FKBP1ALMNAALDH1A1 | |
| SCHEMBL643835 | 0.85 | FKBP1A (0.42) | POLBSIGMAR1FKBP1ALMNAALDH1A1 | |
| SCHEMBL644459 | 0.83 | POLB (0.40) | POLBSIGMAR1FKBP1ALMNAALDH1A1 | |
| SCHEMBL644715 | 0.82 | ALDH1A1 (0.41) | POLBSIGMAR1FKBP1ALMNAALDH1A1 | |
| SCHEMBL645657 | 0.82 | HTT (0.40) | POLBSIGMAR1FKBP1ALMNAALDH1A1 | |
| SCHEMBL644387 | 0.81 | ALDH1A1 (0.39) | POLBSIGMAR1FKBP1ALMNAALDH1A1 | |
| SCHEMBL2491899 | 0.79 | ALDH1A1 (0.37) | POLBSIGMAR1FKBP1ALMNAALDH1A1 | |
| SCHEMBL644037 | 0.79 | ALDH1A1 (0.37) | POLBSIGMAR1FKBP1ALMNAALDH1A1 | |
| SCHEMBL644038 | 0.79 | ALDH1A1 (0.37) | POLBSIGMAR1FKBP1ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119633-B2 | N-{2-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-2-oxo-ethoxy]-ethyl}-N-ethyl-4-methoxy-2,3,6-trimethyl-phenylsulfonamide; condensing the N-carboxyalkyl phenylsulfonamide with the substituted piperidine; bradykinin receptor antagonists; analgesics; antidiabetics; angiogenesis inhibitors; rheumatic diseases | GRUENENTHAL GMBH (DE) | 2012-02-21 | — | — | US | disclosed |