Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31190825 | 0.87 | HPGD (0.64) | HPGDTSHRALDH1A1DPP4SMN1; SMN2 | |
| SCHEMBL4925533 | 0.87 | HPGD (0.64) | HPGDTSHRALDH1A1DPP4SMN1; SMN2 | |
| SCHEMBL4922166 | 0.87 | HPGD (0.64) | HPGDTSHRALDH1A1DPP4SMN1; SMN2 | |
| SCHEMBL4922178 | 0.87 | HPGD (0.64) | HPGDTSHRALDH1A1DPP4SMN1; SMN2 | |
| SCHEMBL6162246 | 0.82 | HPGD (0.57) | HPGDTSHRALDH1A1DPP4SMN1; SMN2 | |
| SCHEMBL6162353 | 0.82 | HPGD (0.57) | HPGDTSHRALDH1A1DPP4SMN1; SMN2 | |
| SCHEMBL6438945 | 0.76 | NPC1 (0.46) | HPGDSMN1; SMN2NPC1GLARAB9A | |
| SCHEMBL6159065 | 0.76 | HPGD (0.50) | HPGDTSHRDPP4SMN1; SMN2HTT | |
| SCHEMBL6161961 | 0.76 | HPGD (0.50) | HPGDTSHRALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL6158312 | 0.76 | HPGD (0.50) | HPGDTSHRALDH1A1DPP4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325146-B1 | PROCESS FOR PREPARING OPTICALLY ACTIVE 4-HYDROXY-2-PYRROLIDINONE AND N-SUBSTITUTED 4-HYDROXY-2-PYRROLIDINONES BY ENZYMATIC HYDROXYLATION | EIDGENOESSICHE TECH HOCHSCHULE (CH) | 2005-12-14 | — | — | EP | claimed |