Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 15/20 | 0.50 |
| ▸ | CTSS | P25774 | 11/20 | 0.50 |
| ▸ | CTSL | P07711 | 8/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6446969 | 0.90 | KDM4E (0.44) | CTSKCTSSCTSLKDM4ETAAR1 | |
| SCHEMBL6442329 | 0.89 | ATM (0.51) | CTSKCTSSCTSLCTSBATM | |
| SCHEMBL5525516 | 0.87 | CTSK (0.53) | CTSKCTSSCTSLCTSBATM | |
| SCHEMBL6442268 | 0.87 | KDM4E (0.58) | CTSKCTSSCTSLKDM4ETAAR1 | |
| SCHEMBL6441987 | 0.86 | CTSK (0.46) | CTSKCTSSCTSLCTSB | |
| SCHEMBL6449654 | 0.85 | CTSK (0.56) | CTSKCTSSCTSLKDM4ETAAR1 | |
| SCHEMBL4713174 | 0.83 | CTSK (0.70) | CTSKCTSSCTSLCTSB | |
| SCHEMBL6444054 | 0.83 | CTSS (0.50) | CTSKCTSSCTSLCTSBCYP3A4 | |
| SCHEMBL6446493 | 0.81 | CTSL (0.53) | CTSKCTSSCTSLCTSBATM | |
| SCHEMBL6447319 | 0.81 | CTSK (0.48) | CTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | claimed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | claimed |
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | disclosed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | disclosed |