Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.43 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5283650 | 0.85 | AKR1B1 (0.52) | GPR84FFAR1PPARDTDP1AKR1B1 | |
| SCHEMBL22500721 | 0.85 | GPR84 (0.50) | CA2MAPK1ACE2GPR84FFAR1 | |
| SCHEMBL22345156 | 0.85 | DNM1 (0.47) | CA2MAPK1CA1FDPSTDP1 | |
| SCHEMBL3185161 | 0.85 | DNM1 (0.47) | CA2MAPK1CA1FDPSTDP1 | |
| SCHEMBL5878832 | 0.84 | AKR1B1 (0.62) | GPR84FFAR1MAPTPPARDTDP1 | |
| Bicarbonate SCHEMBL19582709 | 0.83 | CA2 (0.52) | CA2MAPK1ACE2GPR84CA1 | |
| Bicarbonate SCHEMBL8576736 | 0.83 | CA2 (0.52) | CA2MAPK1ACE2GPR84CA1 | |
| SCHEMBL20489965 | 0.82 | CA2 (0.41) | CA2MAPK1ACE2GPR84CA1 | |
| SCHEMBL6250281 | 0.82 | CA2 (0.52) | CA2MAPK1ACE2GPR84CA1 | |
| SCHEMBL905445 | 0.82 | CA2 (0.52) | CA2MAPK1ACE2GPR84CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0982342-B1 | Polyamide having excellent stretching properties | UBE INDUSTRIES (JP) | 2005-03-23 | — | — | EP | claimed |