Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9669271 | 0.66 | KMT2A (0.41) | MAPTALDH1A1GAAHPGDPOLB | |
| SCHEMBL6443180 | 0.65 | KMT2A (0.34) | MAPTALDH1A1HPGDNPSR1KMT2A | |
| SCHEMBL3598235 | 0.65 | HPGD (0.57) | ALDH1A1HPGDPOLB | |
| SCHEMBL26025586 | 0.65 | HPGD (0.57) | ALDH1A1HPGDPOLB | |
| SCHEMBL23394177 | 0.65 | HPGD (0.57) | ALDH1A1HPGDPOLB | |
| SCHEMBL18280147 | 0.61 | MGLL (0.58) | — | |
| SCHEMBL29051134 | 0.61 | MEN1 (0.58) | MAPTALDH1A1HPGDTSHRKMT2A | |
| SCHEMBL12487561 | 0.60 | HPGD (0.55) | ALDH1A1GAAHPGDGLATDP1 | |
| SCHEMBL12959086 | 0.60 | NPC1 (0.53) | MAPK1KMT2ACHRNB2CHRNA5CHRNA7 | |
| SCHEMBL9354623 | 0.60 | ALDH1A1 (0.66) | ALDH1A1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1256588-B1 | NOVEL PYRAZINE DERIVATIVES OR SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES OR THE SALTS AND INTERMEDIATES FOR THE PREPARATION OF BOTH | TOYAMA CHEMICAL CO LTD (JP) | 2005-02-02 | — | — | EP | disclosed |