Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.35 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5176743 | 0.81 | PDE4B (0.39) | LRRK2PDE4BPDE7APDE1BMAPK1 | |
| SCHEMBL6437921 | 0.77 | PDE4B (0.40) | LRRK2PDE4BPDE7AMAPK1EML4 | |
| SCHEMBL3422561 | 0.71 | LMNA (0.38) | PDE4BPDE7ABRD4 | |
| SCHEMBL4762000 | 0.69 | ALDH1A1 (0.35) | PDE4BPDE7A | |
| SCHEMBL22572990 | 0.69 | LRRK2 (0.45) | LRRK2PDE4BPDE1BMAPK1MAPK8 | |
| SCHEMBL22573150 | 0.69 | MAPK1 (0.40) | LRRK2PDE4BPDE7AMAPK1EML4 | |
| SCHEMBL31498503 | 0.68 | MAPK1 (0.49) | LRRK2PDE4BPDE7AMAPK1MAPK8 | |
| SCHEMBL4552449 | 0.67 | RAB9A (0.40) | LRRK2PDE4BPDE7A | |
| SCHEMBL22573136 | 0.66 | MAPK1 (0.46) | LRRK2PDE4BPDE7AMAPK1BRD4 | |
| SCHEMBL4951461 | 0.66 | LRRK2 (0.44) | LRRK2PDE4BPDE7APDE1BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539753-A2 | PYRAZOLO(3,4-B)PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-15 | — | — | EP | claimed |
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | claimed |