Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | BMP1 | P13497 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664187 | 0.87 | HDAC1 (0.52) | SMN1; SMN2HDAC1HDAC2HDAC3HPGD | |
| SCHEMBL5564847 | 0.85 | RXFP1 (0.44) | RAB9ANPC1SMN1; SMN2L3MBTL1RXFP1 | |
| SCHEMBL6444273 | 0.84 | HTR1B (0.46) | RAB9ANPC1SMN1; SMN2ALDH1A1HTR1B | |
| SCHEMBL5563510 | 0.83 | RAB9A (0.48) | RAB9ANPC1SMN1; SMN2L3MBTL1HDAC1 | |
| SCHEMBL6280292 | 0.83 | NPC1 (0.65) | RAB9ANPC1SMN1; SMN2L3MBTL1HDAC1 | |
| SCHEMBL5564958 | 0.80 | RXFP1 (0.45) | RAB9ANPC1SMN1; SMN2L3MBTL1HDAC1 | |
| SCHEMBL3664185 | 0.80 | HDAC1 (0.49) | HDAC1HDAC2HDAC3KDR | |
| SCHEMBL5559604 | 0.79 | LMNA (0.49) | RAB9ANPC1SMN1; SMN2ALDH1A1HTR1B | |
| Anthranilamide SCHEMBL6444259 | 0.79 | CYP1A2 (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1HTR1B | |
| SCHEMBL3661175 | 0.76 | HDAC2 (0.52) | SMN1; SMN2HDAC1HDAC2HDAC3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594857-A2 | N-MONOACYLATED O-PHENYLENEDIAMINES AS ANTI-CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-16 | — | — | EP | claimed |
| WO-2004069133-A2 | N-MONOACYLATED O-PHENYLENEDIAMINES AS ANTI -CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-19 | — | — | WO | claimed |