Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5559604 | 0.93 | LMNA (0.49) | HTR1BKMT2ASMN1; SMN2MEN1NPC1 | |
| Anthranilamide SCHEMBL6444259 | 0.92 | CYP1A2 (0.47) | HTR1BKMT2ASMN1; SMN2MEN1NPC1 | |
| SCHEMBL5559227 | 0.87 | HTR1B (0.50) | HTR1BKMT2ASMN1; SMN2MEN1NPC1 | |
| SCHEMBL6444267 | 0.84 | RAB9A (0.47) | HTR1BKMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL6280297 | 0.81 | KMT2A (0.68) | KMT2ASMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL5565039 | 0.81 | LMNA (0.46) | KMT2ASMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL6982551 | 0.80 | MAPK1 (0.49) | HTR1BKMT2ASMN1; SMN2MEN1NPC1 | |
| SCHEMBL5565438 | 0.78 | LMNA (0.55) | KMT2ASMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL5558971 | 0.78 | LMNA (0.50) | KMT2ASMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL2649753 | 0.77 | KMT2A (0.59) | KMT2ASMN1; SMN2MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594857-A2 | N-MONOACYLATED O-PHENYLENEDIAMINES AS ANTI-CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-16 | — | — | EP | claimed |
| WO-2004069133-A2 | N-MONOACYLATED O-PHENYLENEDIAMINES AS ANTI -CANCER AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-19 | — | — | WO | claimed |