Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19710084 | 0.93 | SMYD3 (0.60) | KMT2AMEN1SMYD3OPRM1OPRD1 | |
| SCHEMBL14002084 | 0.83 | SIGMAR1 (0.57) | KMT2AMEN1POLB | |
| SCHEMBL27470508 | 0.82 | KMT2A (0.57) | KMT2AMEN1SMYD3OPRM1OPRD1 | |
| SCHEMBL13647331 | 0.81 | KMT2A (0.56) | KMT2AMEN1SMYD3OPRM1OPRD1 | |
| SCHEMBL8268852 | 0.81 | KMT2A (0.56) | KMT2AMEN1SMYD3OPRM1OPRD1 | |
| SCHEMBL12586554 | 0.79 | KMT2A (0.48) | KMT2AMEN1SMYD3OPRM1OPRD1 | |
| SCHEMBL12586571 | 0.79 | KMT2A (0.48) | KMT2AMEN1SMYD3OPRM1OPRD1 | |
| SCHEMBL15564697 | 0.78 | HTT (0.55) | KMT2AMEN1 | |
| SCHEMBL18569491 | 0.78 | HTT (0.55) | KMT2AMEN1 | |
| SCHEMBL15564695 | 0.78 | HTT (0.55) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1604662-A1 | 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft (DE) | 2005-12-14 | — | — | EP | disclosed |