SCHEMBL6445069

SCHEMBL6445069

CC(CCl)CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C

nearest known ligand 0.51

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SMYD2 Q9NRG4 3/20 0.38
CYP3A4 P08684 1/20 0.34
HTT P42858 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
TRPA1 O75762 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13134295 0.85 SMYD2 (0.36) SMYD2CYP3A4HTTSMN1; SMN2
SCHEMBL9007744 0.85 SMYD2 (0.36) SMYD2CYP3A4HTTSMN1; SMN2
SCHEMBL5030605 0.84 TRPA1 (0.39) SMYD2CYP3A4HTTSMN1; SMN2TRPA1
SCHEMBL4337323 0.84 SMYD2 (0.35) SMYD2CYP3A4HTTSMN1; SMN2
SCHEMBL5030604 0.84 TRPA1 (0.39) SMYD2CYP3A4HTTSMN1; SMN2TRPA1
SCHEMBL7051126 0.84 SMYD2 (0.35) SMYD2CYP3A4HTTSMN1; SMN2
SCHEMBL18666927 0.84 SCN4A (0.39) SMYD2CYP3A4HTTSMN1; SMN2
SCHEMBL5026308 0.84 SMYD2 (0.35) SMYD2CYP3A4HTTSMN1; SMN2
SCHEMBL22128202 0.84 SCN4A (0.39) SMYD2CYP3A4HTTSMN1; SMN2
SCHEMBL5026304 0.84 SMYD2 (0.35) SMYD2CYP3A4HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6858679-B2 Compositions providing improved functionalization of terminal anions and processes for improved functionalization of terminal anions FMC CORPORATION (US) 2005-02-22 US disclosed
EP-1028982-B1 COMPOSITIONS PROVIDING IMPROVED FUNCTIONALIZATION OF TERMINAL ANIONS AND PROCESSES FOR IMPROVED FUNCTIONALIZATION OF TERMINAL ANIONS FMC CORP (US) 2003-10-29 EP disclosed
US-20030153693-A1 Compositions providing improved functionalization of terminal anions and processes for improved functionalization of terminal anions QUIRK RODERIC PAUL (US) 2003-08-14 US disclosed
US-6605564-B1 Anionic polymerization initiators and salt additives selected from sodium chloride, sodium iodide, potassium chloride, potassium t-butoxide, for increasing the efficiency of reactions between living polymer anions and electrophiles FMC CORPORATION 2003-08-12 US disclosed
US-6545103-B2 Living polymers FMC CORPORATION 2003-04-08 US disclosed
US-20020010082-A1 Compositions providing improved functionalization of terminal anions and processes for improved functionalization of terminal anions FMC CORPORATION 2002-01-24 US disclosed
EP-1028982-A1 COMPOSITIONS PROVIDING IMPROVED FUNCTIONALIZATION OF TERMINAL ANIONS AND PROCESSES FOR IMPROVED FUNCTIONALIZATION OF TERMINAL ANIONS FMC CORPORATION (US) 2000-08-23 EP disclosed
WO-1999025740-A1 COMPOSITIONS PROVIDING IMPROVED FUNCTIONALIZATION OF TERMINAL ANIONS AND PROCESSES FOR IMPROVED FUNCTIONALIZATION OF TERMINAL ANIONS FMC CORPORATION (US) 1999-05-27 WO disclosed