Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.39 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5030605 | 1.00 | TRPA1 (0.39) | TRPA1SMYD2CYP3A4HTTSMN1; SMN2 | |
| SCHEMBL5923195 | 1.00 | TRPA1 (0.39) | TRPA1SMYD2CYP3A4HTTSMN1; SMN2 | |
| SCHEMBL8466374 | 0.89 | TRPA1 (0.36) | TRPA1SMYD2CYP3A4HTTSMN1; SMN2 | |
| SCHEMBL23689304 | 0.88 | TRPA1 (0.41) | TRPA1SMYD2CYP3A4HTTSMN1; SMN2 | |
| SCHEMBL14481752 | 0.88 | TRPA1 (0.41) | TRPA1SMYD2CYP3A4HTTSMN1; SMN2 | |
| SCHEMBL27450106 | 0.88 | TRPA1 (0.41) | TRPA1SMYD2CYP3A4HTTSMN1; SMN2 | |
| SCHEMBL218117 | 0.85 | CYP1A2 (0.42) | CYP3A4HTTSMN1; SMN2LMNACYP1A2 | |
| SCHEMBL2531862 | 0.85 | CYP1A2 (0.42) | CYP3A4HTTSMN1; SMN2LMNACYP1A2 | |
| SCHEMBL21873649 | 0.85 | CYP1A2 (0.42) | CYP3A4HTTSMN1; SMN2LMNACYP1A2 | |
| SCHEMBL9007744 | 0.85 | SMYD2 (0.36) | SMYD2CYP3A4HTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114644627-B | AhR inhibitors and uses thereof | 山东轩竹医药科技有限公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-115698005-B | Fused ring AhR inhibitors | 山东轩竹医药科技有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-116940552-A | Spirocyclic hexane derivatives, pharmaceutical compositions containing them and their use as anti-apoptotic inhibitors | 法国施维雅药厂 | 2023-10-24 | — | — | CN | disclosed |
| US-11634449-B2 | Macrolides and methods of their preparation and use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-25 | — | — | US | disclosed |
| US-20230109357-A1 | 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-06 | — | — | US | disclosed |
| CN-115698005-A | Fused ring AhR inhibitors | 山东轩竹医药科技有限公司 | 2023-02-03 | — | — | CN | disclosed |
| EP-4095146-A1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | President And Fellows Of Harvard College (US) | 2022-11-30 | — | — | EP | disclosed |
| US-20220332747-A1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-10-20 | — | — | US | disclosed |
| US-11466046-B2 | 14-membered ketolides and methods of their preparation and use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-10-11 | — | — | US | disclosed |
| WO-2022127753-A1 | FUSED RING AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-06-23 | — | — | WO | disclosed |
| WO-2016057798-A1 | 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-04-14 | — | — | WO | disclosed |
| WO-2016057798-A1 | 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-04-14 | — | — | WO | disclosed |
| EP-2988597-A2 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | President and Fellows of Harvard College (US) | 2016-03-02 | — | — | EP | disclosed |
| US-20160052951-A1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-02-25 | — | — | US | disclosed |
| WO-2014165792-A2 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-10-09 | — | — | WO | disclosed |
| WO-2014165792-A2 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-10-09 | — | — | WO | disclosed |
| EP-1939191-A1 | Furan derivatives, method of synthesis and uses thereof | Neuropharma S.A. (ES) | 2008-07-02 | — | — | EP | disclosed |
| US-6982257-B1 | Vitamin D3 derivative and its production method | TEIJIN LIMITED (JP) | 2006-01-03 | — | — | US | disclosed |
| EP-0957088-B1 | VITAMIN D3 DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | TEIJIN LTD (JP) | 2002-12-18 | — | — | EP | disclosed |
| EP-0957088-A1 | VITAMIN D3 DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | TEIJIN LIMITED (JP) | 1999-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11466046-B2 | 14-membered ketolides and methods of their preparation and use | CYP51A1, KHK, HSD17B7 | TRPA1 4795/4885SMYD2 3583/4885CYP3A4 12/4885 |
| US-20220332747-A1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | CYP11B2, ERG28, DHCR7 | TRPA1 4643/4885SMYD2 2895/4885CYP3A4 133/4885 |
| US-20160052951-A1 | MACROLIDES AND METHODS OF THEIR PREPARATION AND USE | CYP11B2, ERG28, DHCR7 | TRPA1 4643/4885SMYD2 2895/4885CYP3A4 133/4885 |
| US-11634449-B2 | Macrolides and methods of their preparation and use | CYP11B2, ERG28, DHCR7 | TRPA1 4643/4885SMYD2 2895/4885CYP3A4 133/4885 |
| US-20230109357-A1 | 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE | CYP51A1, KHK, HSD17B7 | TRPA1 4795/4885SMYD2 3583/4885CYP3A4 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.