SCHEMBL6445763

SCHEMBL6445763

Cc1cn([C@@H]2O[C@H](C(OOP(=O)(O)O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]c1=O

nearest known ligand 0.52

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DNPH1 O43598 1/20 0.42
P2RY6 Q15077 3/20 0.42
TK1 P04183 4/20 0.42
TYMP P19971 3/20 0.42
P2RY2 P41231 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15855027 0.85 DNPH1 (0.45) DNPH1P2RY6TK1TYMPP2RY2
SCHEMBL11404005 0.85 DNPH1 (0.45) DNPH1P2RY6TK1TYMPP2RY2
SCHEMBL288450 0.83 TK1 (0.56) TK1
SCHEMBL1704984 0.81 P2RY2 (0.54) P2RY6P2RY2
Phosphoric Acid SCHEMBL9576797 0.80 P2RY2 (0.53) P2RY6P2RY2
SCHEMBL15164434 0.80 LMNA (0.50) TK1
SCHEMBL932061 0.79 LMNA (0.43) DNPH1P2RY6TK1TYMPP2RY2
SCHEMBL4463943 0.78 P2RY6 (0.48) DNPH1P2RY6P2RY2
SCHEMBL3058777 0.76 TK1 (0.43) TK1TYMP
SCHEMBL8422445 0.74 LMNA (0.52) TYMP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1011688-B1 USE OF URIDINE 5'-DIPHOSPHATE AND ANALOGS THEREOF FOR THE TREATMENT OF LUNG DISEASES UNIV NORTH CAROLINA (US) 2005-02-02 EP claimed