Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.56 |
| ▸ | CTSS | P25774 | 4/20 | 0.48 |
| ▸ | CTSB | P07858 | 3/20 | 0.48 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | HSPA5 | P11021 | 4/20 | 0.43 |
| ▸ | HSPA2 | P54652 | 2/20 | 0.43 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.43 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6447088 | 0.91 | CTSL (0.68) | CTSLCTSSCTSBCTSKHSPA5 | |
| SCHEMBL6818989 | 0.87 | CTSL (0.54) | CTSLCTSSCTSBCTSKHSPA5 | |
| SCHEMBL6443368 | 0.85 | CTSL (0.53) | CTSLCTSSCTSBCTSKHSPA5 | |
| SCHEMBL6019209 | 0.83 | CTSL (0.67) | CTSLCTSSCTSBCTSKRAB9A | |
| SCHEMBL6443712 | 0.83 | CTSL (0.51) | CTSLCTSSCTSBHSPA5HSPA2 | |
| SCHEMBL6443295 | 0.81 | CTSB (0.53) | CTSLCTSSCTSBCTSKHSPA5 | |
| SCHEMBL6019617 | 0.80 | CTSL (0.53) | CTSLCTSSCTSBCTSKRAB9A | |
| SCHEMBL16993875 | 0.80 | CTSL (0.57) | CTSLHSPA5HSPA2HSPA1AHSPA9 | |
| SCHEMBL16993982 | 0.80 | CTSL (0.57) | CTSLHSPA5HSPA2HSPA1AHSPA9 | |
| SCHEMBL6020053 | 0.79 | CTSL (0.50) | CTSLCTSSCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | claimed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | claimed |
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | disclosed |