Sugi Predict

Sugi Predict / Compounds / SCHEMBL6445936

SCHEMBL6445936

SCHEMBL6445936

O=C(COc1ccc(Cl)cc1)N1CCC(Oc2ccccc2)CC1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.64
▸ KMT2A Q03164 2/20 0.64
▸ GPR183 P32249 1/20 0.64
▸ POLB P06746 2/20 0.61
▸ MAPT P10636 2/20 0.61
▸ HPGD P15428 1/20 0.61
▸ RAB9A P51151 1/20 0.61
▸ SMN1; SMN2 Q16637 3/20 0.61
▸ L3MBTL1 Q9Y468 2/20 0.61
▸ ATF4 P18848 1/20 0.61
▸ ALDH1A1 P00352 4/20 0.59
▸ PKM P14618 2/20 0.59
▸ ENPP2 Q13822 2/20 0.58
▸ LMNA P02545 3/20 0.56
▸ EPHX2 P34913 2/20 0.56
▸ KDM4E B2RXH2 1/20 0.55
▸ TDP1 Q9NUW8 1/20 0.55
▸ CHRM2 P08172 1/20 0.55
▸ MAPK1 P28482 1/20 0.54
▸ CYP2C9 P11712 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6443342 0.89 POLB (0.60) MEN1KMT2AGPR183POLBMAPT
SCHEMBL19702690 0.82 SMN1; SMN2 (0.55) MEN1KMT2AGPR183POLBMAPT
SCHEMBL4533467 0.82 POLB (0.76) MEN1KMT2AGPR183POLBMAPT
SCHEMBL5792309 0.82 GRIN2D (0.64) MEN1KMT2AGPR183POLBMAPT
SCHEMBL4576825 0.81 EPHX2 (0.56) MEN1KMT2APOLBMAPTHPGD
SCHEMBL27979662 0.81 POLB (0.84) MEN1KMT2AGPR183POLBMAPT
SCHEMBL19702646 0.81 KMT2A (0.55) MEN1KMT2APOLBMAPTRAB9A
SCHEMBL19702931 0.81 KMT2A (0.55) MEN1KMT2APOLBMAPTRAB9A
SCHEMBL19702653 0.81 KMT2A (0.55) MEN1KMT2APOLBMAPTRAB9A
SCHEMBL29912754 0.81 GAA (0.66) MEN1KMT2APOLBMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1534677-A1 PIPERIDINE DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1ALPHA BINDING TO ITS RECEPTOR CCR1 Pfizer Products Inc. (US) 2005-06-01 — — EP claimed
US-20040063759-A1 Novel piperidine derivatives PFIZER INC. 2004-04-01 — — US claimed
WO-2004009550-A1 PIPERIDINE DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1ALPHA BINDING TO ITS RECEPTOR CCR1 PFIZER PRODUCTS INC. (US) 2004-01-29 — — WO claimed
EP-1534677-A1 PIPERIDINE DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1ALPHA BINDING TO ITS RECEPTOR CCR1 Pfizer Products Inc. (US) 2005-06-01 — — EP disclosed
US-20040063759-A1 Novel piperidine derivatives PFIZER INC. 2004-04-01 — — US disclosed
WO-2004009550-A1 PIPERIDINE DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1ALPHA BINDING TO ITS RECEPTOR CCR1 PFIZER PRODUCTS INC. (US) 2004-01-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040063759-A1 Novel piperidine derivatives CCR1, CCR3, CCR2 MEN1 4730/4885KMT2A 3551/4885GPR183 406/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.