Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | EED | O75530 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8534452 | 0.80 | SLC6A4 (0.49) | SLC6A2SLC6A4SLC6A3HTR2CHTR2B | |
| SCHEMBL7353471 | 0.77 | EED (0.52) | SLC6A2SLC6A4SLC6A3HTR2CEED | |
| SCHEMBL1637555 | 0.74 | HTR2C (0.56) | HTR2CEEDADRB1HTR2AHTR2B | |
| SCHEMBL1637389 | 0.74 | HTR2C (0.56) | HTR2CEEDADRB1HTR2AHTR2B | |
| SCHEMBL1636847 | 0.74 | HTR2C (0.56) | HTR2CEEDADRB1HTR2AHTR2B | |
| SCHEMBL6455895 | 0.72 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3HTR2CADRB1 | |
| SCHEMBL27730686 | 0.72 | POLB (0.50) | SLC6A2SLC6A4SLC6A3HTR2CPOLB | |
| SCHEMBL12330901 | 0.70 | POLB (0.49) | SLC6A2SLC6A4SLC6A3HTR2CEED | |
| SCHEMBL12330950 | 0.70 | POLB (0.49) | SLC6A2SLC6A4SLC6A3HTR2CEED | |
| SCHEMBL6447627 | 0.70 | SLC6A4 (0.43) | SLC6A2SLC6A4SLC6A3HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492794-A1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES AND THEIR USE AS DOPAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PSYCHOTIC DISORDERS | ELI LILLY AND COMPANY (US) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082877-A1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES AND THEIR USE AS DOPAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PSYCHOTIC DISORDERS | ELI LILLY AND COMPANY (US) | 2003-10-09 | — | — | WO | disclosed |