Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 5/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6446174 | 0.80 | SLC6A2 (0.51) | SLC6A4SLC6A2SLC6A3HTR2CHTR2B | |
| SCHEMBL27720231 | 0.79 | SLC6A4 (0.41) | SLC6A4SLC6A2SLC6A3CYP2D6HTR6 | |
| SCHEMBL16757084 | 0.73 | SLC6A2 (0.45) | SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL6447627 | 0.72 | SLC6A4 (0.43) | SLC6A4SLC6A2SLC6A3HTR2C | |
| SCHEMBL8531021 | 0.71 | SLC6A4 (0.41) | SLC6A4SLC6A2SLC6A3HTR6 | |
| SCHEMBL7007764 | 0.71 | SLC6A2 (0.37) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL552077 | 0.70 | SLC6A3 (0.46) | SLC6A4SLC6A2SLC6A3CYP2D6HTR6 | |
| SCHEMBL6504554 | 0.70 | SLC6A2 (0.35) | SLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL6540298 | 0.69 | SLC6A2 (0.36) | SLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL6336901 | 0.69 | SLC6A2 (0.36) | SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739334-A | CHEMICAL INTERMEDIATES FOR NEW ANTIDEPRESSANT WITH SIDE EFFECT REDUCTION | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1998-04-14 | — | — | US | disclosed |
| US-5726178-A | Alkyl derivatives of trazodone with CNS activity | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1998-03-10 | — | — | US | disclosed |
| US-5543563-A | ANTIDEPRESSANTS; SIDE EFFECT REDUCTION | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1996-08-06 | — | — | US | disclosed |
| EP-0623131-B1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY | ANGELINI RICERCHE SPA (IT) | 1996-04-03 | — | — | EP | disclosed |
| EP-0623131-A1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY. | ANGELINI FRANCESCO IST RICERCA (IT) | 1994-11-09 | — | — | EP | disclosed |
| WO-1993014091-A1 | ALKYL DERIVATIVES OF TRAZODONE WITH CNS ACTIVITY | ISTITUTO RICERCA FRANCESCO ANGELINI S.P.A. (IT) | 1993-07-22 | — | — | WO | disclosed |