SCHEMBL6446432

SCHEMBL6446432

Cc1ncccc1C(Br)C=O

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TRIM24 O15164 1/20 0.36
TRIM33 Q9UPN9 1/20 0.36
NPC1 O15118 1/20 0.35
HSP90AA1 P07900 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
P2RX7 Q99572 1/20 0.35
MKNK1 Q9BUB5 1/20 0.33
MKNK2 Q9HBH9 1/20 0.33
HRH1 P35367 1/20 0.32
NOS3 P29474 1/20 0.31
NOS1 P29475 1/20 0.31
NOS2 P35228 1/20 0.31
ERN1 O75460 2/20 0.31
GSK3B P49841 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4591153 0.79 TRIM24 (0.50) TRIM24TRIM33GSK3B
SCHEMBL11028781 0.78 NOS3 (0.37) NPC1HSP90AA1L3MBTL1P2RX7MKNK1
SCHEMBL4591185 0.78 TRIM24 (0.40) TRIM24TRIM33NPC1
SCHEMBL20602053 0.78 TRIM24 (0.40) TRIM24TRIM33NPC1
SCHEMBL27615013 0.77 P2RX7 (0.36) TRIM24TRIM33P2RX7MKNK1MKNK2
SCHEMBL15228400 0.75 PSMD14 (0.47) HSP90AA1L3MBTL1ERN1
SCHEMBL21495018 0.74 NOS3 (0.39) TRIM24TRIM33NPC1HSP90AA1L3MBTL1
SCHEMBL4541614 0.74 NOS3 (0.39) TRIM24TRIM33NPC1HSP90AA1L3MBTL1
SCHEMBL27707670 0.74 P2RX7 (0.36) P2RX7MKNK1MKNK2HRH1
SCHEMBL168886 0.72 ESR1 (0.45) HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1583742-A1 NOVEL CB 1 RECEPTOUR INVERSE AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2005-10-12 EP disclosed
EP-1480976-A1 THIAZOLE DERIVATIVES AS NPY RECEPTOR ANTAGONISTS F.HOFFMANN-LA ROCHE AG (CH) 2004-12-01 EP disclosed
WO-2004060870-A1 NOVEL CB 1 RECEPTOUR INVERSE AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2004-07-22 WO disclosed
WO-2003072577-A1 THIAZOLE DERIVATIVES AS NPY RECEPTOR ANTAGONISTS F.HOFFMANN-LA ROCHE AG (CH) 2003-09-04 WO disclosed