Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 8/20 | 0.45 |
| ▸ | CTSK | P43235 | 7/20 | 0.45 |
| ▸ | CTSS | P25774 | 6/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | KAT2A | Q92830 | 2/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6447617 | 0.91 | CTSK (0.37) | CTSLCTSKCTSSALOX5KAT2A | |
| SCHEMBL6448205 | 0.85 | CTSL (0.47) | CTSLCTSKCTSSALOX5CTSB | |
| SCHEMBL6443383 | 0.85 | CTSS (0.51) | CTSLCTSKCTSSALOX5CTSC | |
| SCHEMBL6444143 | 0.83 | CTSK (0.45) | CTSLCTSKCTSSALOX5CTSC | |
| SCHEMBL6021888 | 0.82 | CTSK (0.44) | CTSLCTSKCTSSALOX5POLB | |
| SCHEMBL6446410 | 0.82 | CTSS (0.48) | CTSLCTSKCTSSALOX5CTSB | |
| SCHEMBL6448203 | 0.82 | CTSS (0.48) | CTSLCTSKCTSSALOX5POLB | |
| SCHEMBL6444043 | 0.81 | CTSS (0.62) | CTSLCTSKCTSSCTSB | |
| SCHEMBL6821937 | 0.81 | CTSK (0.43) | CTSLCTSKCTSSALOX5POLB | |
| SCHEMBL6445530 | 0.81 | CTSS (0.47) | CTSLCTSKCTSSALOX5CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | claimed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | claimed |
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | disclosed |