Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448504 | 0.91 | KDM1A (0.54) | SLC6A4SLC6A2SLC6A3KDM1AOPRM1 | |
| SCHEMBL31499206 | 0.83 | MAOB (0.42) | — | |
| SCHEMBL28001878 | 0.83 | ADRB1 (0.49) | SLC6A4SLC6A2SLC6A3KDM1AOPRM1 | |
| SCHEMBL5221231 | 0.81 | KDM1A (0.53) | KDM1A | |
| SCHEMBL30567205 | 0.81 | OPRM1 (0.59) | SLC6A4SLC6A2SLC6A3KDM1AOPRM1 | |
| SCHEMBL4180702 | 0.81 | OPRM1 (0.59) | SLC6A4SLC6A2SLC6A3KDM1AOPRM1 | |
| Hydrochloric Acid SCHEMBL4464330 | 0.79 | OPRM1 (0.58) | SLC6A4SLC6A2SLC6A3KDM1AOPRM1 | |
| SCHEMBL22538479 | 0.79 | OPRM1 (0.54) | SLC6A4SLC6A2SLC6A3KDM1AOPRM1 | |
| SCHEMBL17982834 | 0.79 | KDM1A (0.54) | SLC6A4SLC6A2SLC6A3KDM1A | |
| SCHEMBL6831189 | 0.79 | OPRM1 (0.61) | SLC6A4SLC6A2SLC6A3KDM1AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066742-A1 | BACE-2 INHIBITORY COMPOUNDS AND RELATED METHODS OF USE | JORTAN PHARMACEUTICALS INC. (US) | 2017-04-20 | — | — | WO | disclosed |
| EP-1527077-A2 | PYRROLOPYRAZINES AS KINASE INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004016614-A2 | PYRROLOPYRAZINES AS KINASE INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2004-02-26 | — | — | WO | disclosed |